Exploring the Possible Link: Periodontal Disease and Rheumatoid Arthritis

In recent years, there has been increasing evidence to suggest that periodontal disease is associated with a large number of systemic conditions. Among the best studied of these are diabetes, preterm birth, low birth weight, cardiovascular disease, pulmonary disease, obesity and osteoporosis.¹ Each of these conditions has also been associated with rheumatoid arthritis (Table 1).² While the association between rheumatoid arthritis and these conditions may be due to medication usage, studies have demonstrated that relationships between rheumatoid arthritis and systemic conditions can be detected following removal of the confounding issue of medications.³ A common feature linking these disease associations for both periodontitis and rheumatoid arthritis appears to be the presence of chronic inflammation at both local and systemic levels.^4,5

In light of their similar epidemiological patterns, environmental factors that influence disease manifestation, and comorbidities with similar systemic conditions for both rheumatoid arthritis and periodontitis, an interrelationship between these two conditions seems plausible.

A proposed association between rheumatoid arthritis and periodontitis is not new. As early as 1926, researchers suggested there may be a relationship between arthritis and periodontal disease among individuals with a predisposition to both conditions.⁶ Subsequent studies have been well documented in narrative reviews.^7,8 A systematic review and meta-analysis concluded there is moderate to strong evidence to support an association between rheumatoid arthritis and periodontal disease — and that common risk factors or similar pathologic processes may be responsible for such an association.⁹

A number of important observations can be made from these studies. First, there is no evidence to support the commonly held idea that rheumatoid arthritis patients have impaired oral hygiene due to reduced dexterity — as both control and rheumatoid arthritis patients have similar plaque and bleeding scores.^10,11 Individuals with severe rheumatoid arthritis are more likely to experience advanced periodontitis, and vice versa.¹⁰ The role that medications prescribed for rheumatoid arthritis might play in the manifestation of periodontitis is interesting, but may confound the clinical picture. For example, while most individuals with rheumatoid arthritis take medications that reduce inflammation, significant periodontal destruction is still evident in these patients.¹⁰ This indicates that periodontitis was most likely developing and not detected prior to the manifestation of rheumatoid arthritis symptoms and subsequent use of medication for the arthritis.¹² Thus, determination of the disease duration for both rheumatoid arthritis and periodontal conditions is a critical factor to consider when assessing the relationship between these two conditions. To fully appreciate the associations between periodontitis and rheumatoid arthritis, future studies should aim to document the diseases on the basis of their severity and duration.

PERIODONTAL PATHOGENS AS AN INFECTIVE SOURCE

The claim that rheumatoid arthritis is caused by some form of infectious agent has been postulated for more than 70 years and is still under consideration.¹³ Numerous studies in a variety of animal models have demonstrated that arthritis can develop following exposure to exogenous infections.¹³ While extrapolation from animal models to human disease must be done with caution, the findings from these models lend support to a role for various types of infections in genetically susceptible individuals in the development of human rheumatoid arthritis.¹⁴

The role of Gram-negative bacteria and their byproducts (particularly lipo­poly­saccharide) has long been implicated in the development of rheumatoid arthritis (Figure 1).¹⁵ Clearly, the subgingival plaque associated with periodontitis (mainly Gram-negative anaerobes) could be a potential source of bacteria and bacterial byproducts for bacterial-induced rheumatoid arthritis.¹⁶ Many of the so-called periodontal pathogens exhibit similar characteristics to those microorganisms suspected to induce rheumatoid arthritis in a genetically susceptible host (Table 2). Thus, the possibility that bacteria associated with periodontitis could trigger or exacerbate rheumatoid arthritis in genetically susceptible individuals is biologically possible.

Several studies have demonstrated that patients with rheumatoid arthritis, compared to nonrheumatoid arthritis controls, have elevated antibodies in their serum against several bacteria associated with periodontitis. These includes Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaninogenica, Bacteroides forsythus and Aggregatibacter actinomycetemcomitans.^17,18 Furthermore, elevated antibodies and DNA for B. forsythus, P. intermedia, P. gingivalis and Fusobacterium nucleatum have also been identified in synovial fluid.^19–21 These findings suggest that periodontal pathogens may translocate from the periodontal tissues to the joints, where they could exacerbate the inflammatory processes occurring within rheumatoid joints.

CITRULLINATED PROTEINS AND AUTOIMMUNITY

During the course of inflammation, proteins may undergo a process called citrullination that results in a structural change to proteins through conversion of the amino acid arginine to citrulline.²² Citrullination of proteins arises from the action of enzymes, known as peptidyl arginine deiminases (PAD). The change in protein structure as a result of citrullination results in proteins becoming antigenic, which leads to the production of anticitrullinated peptide antibodies. The inflamed periodontium is a potential site where citrullination can occur, and anticitrullinated antibodies can result from this process.²³ If such antibodies are produced at sites of inflammation (i.e., during the development of periodontitis) prior to inflammation developing in the joints, the possibility of an enhanced antibody reaction occurring is very high once joint inflammation associated with rheumatoid arthritis develops.²⁴ Importantly, anticitrullinated peptide antibodies have a high predictive value for rheumatoid arthritis onset several years before it is evident clinically, and are also associated with more severe clinical outcomes.^25,26

Importantly, P. gingivalis has been reported to be the only bacterium known to produce a PAD enzyme capable of causing protein citrullination.²⁷ Should this bacterial enzyme be able to gain access to the periodontal tissues and be actively involved in protein citrullination in patients with periodontitis, an additional pathway is developed.²⁸ This concept provides a novel link between periodontal infection and the development of rheumatoid arthritis (Figure 2).

THE “TWO-HIT” MODEL

The primed inflammatory response — or “two-hit” — model has been proposed to explain how periodontitis and rheumatoid arthritis might be interrelated.²⁹ It suggests that a primary hit of chronic inflammation via chronic periodontitis, followed by a secondary inflammatory hit in the joints to induce rheumatoid arthritis can lead to an exacerbated inflammatory response (Figure 3). These heightened responses may lead to increases in numerous mediators of systemic inflammation in the circulation, which may stimulate cells in the joints and periodontium to mediate further tissue destruction.

The most significant clinical relevance for an association between rheumatoid arthritis and periodontitis, however, is the management of patients with both conditions. Even though most clinical protocols for managing rheumatoid arthritis include an assessment for oral pathology and xerostomia (associated with either Sjögren’s disease or medications used in the treatment of rheumatoid arthritis), the signs and symptoms of periodontitis are generally overlooked. This is compounded by the fact that periodontitis, in its early phases, is generally a painless, subtle condition. Its presence often remains undetected until it reaches an advanced stage. If studies can demonstrate that individuals with periodontitis are at higher risk of developing rheumatoid arthritis (or vice versa), then early interventions to assist in controlling the significant tissue destruction noted in both diseases could be implemented.

CONCLUSION

A recent systematic review analyzed the published intervention studies investigating the effect of nonsurgical periodontal treatment on clinical parameters for rheumatoid arthritis in patients experiencing both periodontitis and rheumatoid arthritis.³⁰ This review concluded there is emerging evidence to indicate that periodontal treatment can influence a number of biochemical and clinical markers of rheumatoid arthritis disease activity, including erthryocyte sedimentation rate, levels of tumor necrosis factor-alpha, disease activity score, and anticitrullinated protein antibody levels. The weaknesses of these studies, however, include low subject numbers and short duration (6-month follow-up or less). Therefore, larger population studies with longer follow-up periods are needed to further investigate whether nonsurgical periodontal treatment has any significant effect on clinical indicators of rheumatoid arthritis.

Research demonstrates an association between periodontal disease and rheumatoid arthritis in that they share many of the same manifestations. While causality does not seem to exist between the two diseases, there is a relationship between disease severity and the potential for periodontal infection to either initiate or modulate rheumatoid arthritis. As much remains unknown about this association, more research is needed to explore the possible connection between rheumatoid arthritis and periodontal disease, and what these data may suggest when it comes to prevention and treatment.

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