Study Reveals New Treatment for Periodontitis

RANDYPHOTOS/GETTYIMAGES

Researchers at Penn Dental School of Medicine and the National Institutes of Health have found a new treatment for periodontitis involving a drug the U.S. Food and Drug Administration has approved for psoriasis that blocks the activity of IL-17 and IL-23. Using a mouse-based study, investigators say high levels of these signaling molecules appear to contribute to periodontitis.

In the study, funded by the National Institutes of Dental and Craniofacial Research (NIDCR), researchers identified a mouse form of the human disease leukocyte adhesion deficiency, or LAD. This rare genetic disease causes recurrent bacterial infections and periodontitis in humans, according to the study published in the New England Journal of Medicine.

Led by Niki Moutsopoulos, DDS, PhD, of NIDCR, the team successfully treated a 19-year-old patient with LAD (a chronic nonhealing wound) and severe periodontitis by using the drug that blocks the activity of IL-23. According to the study, after 1 year of treatment, the patient’s periodontitis and skin wound had improved. “This is really exciting because we see that a treatment performed in mice in our laboratory directly paved the way to a novel clinical treatment for a serious disease that was not responsive to any other treatment,” says coauthor George Hajishengallis, DDS, PhD, the Thomas W. Evans Centennial Professor in Penn Dental’s Department of Microbiology.

Add a Comment

Your email address will not be published. Required fields are marked *

Dentsply Sirona Acquires Cleverdent Ltd

York/Salzburg, January 18, 2018. Dentsply Sirona is committed to its mission...

Oral Health America to Award First Program Champion Awards at 28th Annual Gala & Benefit

CHICAGO, January 18, 2018 — Oral Health America (OHA) will present two...

David Preble named Senior Vice President of the ADA Practice Institute

CHICAGO, January 18, 2018 — The American Dental Association (ADA )has...

Jonathan An Receives ADA Foundation Dentsply Sirona Research Award for Dual Degree Candidates 

Jonathan An, DDS, a PhD candidate in oral health sciences at...

LANAP and LAPIP Protocols: Laser Gum Disease Protocols

Over 50% of US adults have gum disease.  Offer your patients...

IRIS HD USB 3.0 Intraoral Camera

Experience the Clarity in High Definition The new IRIS HD USB...

A New Adhesive/Primer Ideal for Indirect Restorations

At BISCO, adhesion is our passion. BISCO prides itself on developing...

KDZ Bruxer® Aesthetic

Bring the strength of full-contour zirconia into the facial zone with...