Clinical Study Evaluates Naproxen Sodium Versus an Opioid Combination in Acute Postsurgical Dental Pain

New clinical researchย has shown that a single 440 mg dose of over-the-counter naproxen sodiumย (NapS)ย is as effective, lasts longer, and is better tolerated than a single dose of a commonly prescribed opioidย for managing acute postsurgical dental pain.
The single-dose study,ย โAnalgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial,โ published online inย Postgraduate Medicine, found that NapSย was at least as effective at hours 0 to 4 and better tolerated than the opioid combination hydrocodone plus acetaminophen 10/650 mg (HYD+APAP). This class of medication is known to have the potential for misuse and addiction.1ย Additionally, the results showed NapS to have a lower incidence of adverse events than HYD+APAP (14.4% versus 39.1%).
โThis study comes at a key time, as opioid addiction and overdose deaths have been declared a public health emergency in the United States,โ2ย notes M. Ted Wong,ย DDS, MHA, an oral healthcare and dental/medical integration consultant.ย โThe results show that NapS may be an effective, non-addictive treatment option for those undergoing dental procedures.โ It is hoped these findings will lead oral health professionals to consider alternative strategies rather than relying on opioids as a first-line defense for pain management.
REFERENCES
- American Dental Association. ADA Dental Drug Handbook: A Quick Reference. Chicago, Ill: American Dental Association; 2019.
- Kuehn B. Opioid Emergency Declared.ย JAMA.ย 2017;318:2418โ2418.