Researchers Map Complete Single-Cell Atlas of Human Teeth

For the first time, scientists at the University of Zurich have mapped a comprehensive atlas of single cells that make up human teeth. The findings may lead to new cell-based approaches to various dental therapeutics. Results from the study, “A Single-Cell Atlas of Human Teeth,” appeared in iScience.

The team was able to distinguish every cell that makes up the dental pulp and periodontium of human teeth by using single-cell sequencing technology. According to the authors, these tissues contain stem cells that hold regenerative potential, yet are susceptible to microbial-linked pathologies that may lead to caries or periodontitis. While dental pulp and periodontal mesenchymal stem cells are similar, researchers suggest their microenvironments are responsible for major functional differences, depending on the cell’s role in tooth function.