Study Identifies Potential New Combination Therapy to Treat Head and Neck Cancer
Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry may have found a new combination therapy to treat advanced head and neck squamous cell carcinoma, according to a recent study.
Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry may have found a new combination therapy to treat advanced head and neck squamous cell carcinoma, according to a recent study.
Using a mouse model of head and neck squamous cell carcinoma, researchers found “that using an anti-PD1 immunotherapy drug in combination with PTC209, an inhibitor that targets the protein BMI1, successfully stopped the growth and spread of cancer, prevented reoccurrences and eliminated cancer stem cells.”
The study, “BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse,” was published in Cell Stem Cell.
