Researchers at the University of Southern California Herman Ostrow School of Dentistry are working to develop a peptide-based film that prevents biofilm formation on dental implants. If successful, the development could lead to new ways for oral health professionals to prevent and manage peri-implant disease, a leading cause of implant failure.
The study, “Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants,” published in the Journal of the Minerals, Metals and Materials Society, demonstrates that the peptide implant-protective film binds to titanium, providing an anchor that supports antimicrobial peptides. The film targets peri-implant pathogens and reduces the speed of biofilm buildup, according to researchers.
While the initial research involves a professionally applied film, the team — which notes that early diagnosis and management of peri-implant disease is vital to successful long-term outcomes — suggests this therapeutic peptide intervention may eventually be available as a water-based rinse for self-care.