Natural Chemicals May Disrupt Decay

While licorice may raise the risk of dental caries, a chemical found in licorice root may prevent plaque buildup on teeth. According to researchers at the University of Edinburgh in Scotland, the natural chemical trans-chalcone blocks the action of a key enzyme responsible for encouraging cariogenic microbial growth, and its use in oral care products may be key to preventing biofilm accumulation.

Supported by Wm. Wrigley Jr. Company, the study, “Molecular Basis of Streptococcus mutans Sortase A Inhibition by the Flavonoid Natural Product Trans-Chalcone,” published online in June by Chemical Communications, suggest that trans-chalcone is capable of inhibiting the action of S. mutans. Investigating the three-dimensional structure of the enzyme Sortase A, which enables bacteria to make biofilms, the researchers analyzed the role trans-chalcone plays in preventing this enzyme from functioning properly. In fact, the licorice root-based chemical was found to inhibit pathogenic proliferation.

Encouraged by the findings, they plan to expand the study to include similar natural products. Their hope is that natural inhibitors will be incorporated into oral health products for long-term preservation of dentition and improved overall health.

One Response

  1. Lawrence Taub July 19, 2017 Reply

Add a Comment

Your email address will not be published. Required fields are marked *

Study Examines Risk for ONJ in Cancer Patients Who Take Bone-Modifying Agents

An investigation by researchers at the University of Michigan Comprehensive Cancer...

Rodrigo Neiva, DDS, MS, Named Chairman of Penn Dental Medicine’s Department of Periodontics

Penn Dental Medicine has appointed Rodrigo Neiva, DDS, MS, as professor...

TRANSYLVANIA UNIVERSITY NAMES INTERIM PRESIDENT

Transylvania University in Lexington, Kentucky,  has appointed John Norton Williams Jr., DMD, MBA,...

CDA Foundation Accepting Applications for Student Loan Repayment Grant

The California Dental Association Foundation is now accepting applications from recent...

A-dec 500
A-dec Introduces the New A-dec 500

Focused on creating a superior doctor and patient experience, the new...

VALO Corded Curing Light
Ultradent Launches VALO™ Grand Corded Curing Light

Ultradent is pleased to announce the newest addition to its award-winning,...

360 Coverage Pros Launches Dentist Professional Liability Program

360 Coverage Pros to offer new insurance option in rapidly changing...

Palmero Introduces Safety Eyewear Products

Palmero Healthcare, a Hu-Friedy subsidiary, is pleased to announce two new...