MMP20 May Initiate Enamel Formation via Basement Membrane Degradation

DragonImages / iStock / Getty Images Plus

Researchers with Ohio State University, in Columbus, gave an oral presentation on “MMP20 May Initiate Enamel Formation via Basement Membrane Degradation,” during the 96th General Session of the International Association for Dental Research (IADR), held in conjunction with the IADR Pan European Regional (PER) Congress in London, England.

In the study, investigators studied whether Matrix metalloproteinase-20 (MMP-20) is capable of cleaving basement membrane proteins and if its temporal expression pattern is consistent with degradation of the basement membrane. MMP-20 expression is restricted to teeth and its malfunction causes amelogenesis imperfecta.

The results show that MMP20 expression was restricted to ameloblasts of the enamel organ and odontoblast of the pulp organ, and that MMP20 is expressed prior to basement membrane degradation. The basement membrane persisted in mice that had their tissue lining destroyed, but was degraded prematurely in MMP20 overexpressing mice, according to the study.

Add a Comment

Your email address will not be published. Required fields are marked *

Older Women Who Experience Tooth Loss at Higher Risk of Hypertension

Postmenopausal women who have experienced tooth loss may be at increased...

New Interprofessional Curriculum Launched 

Oakland University William Beaumont School of Medicine (OUWB) and University of...

Ultradent Introduces Omni-Matrix™ Disposable Retainer and Matrix

SOUTH JORDAN, Utah—Ultradent Products has introduced the Omni-Matrix disposable retainer and...

Mouth of a senior with missing teeth
Tooth Loss May Indicate Malnutrition

Compared to the general population, older adults with only 10 to...

3M Launches New Xerostomia Relief Spray

Anyone who has experienced xerostomia knows that it is frustrating, especially...

Wonder Z-Ring
Wonder Z-Ring Kit

Wonder Z-Ring creates an even heat distribution across the firing tray...

Owandy Radiology’s I-Max 3D Wall-Mounted Unit Receives FDA 510 (k) Clearance

Owandy Radiology Inc, a global leader in the manufacture of dental...

Dentistry.com
Introducing Dentistry.Com

Futuredontics, a wholly owned subsidiary of Dentsply Sirona, announced the launch...