MMP20 May Initiate Enamel Formation via Basement Membrane Degradation

DragonImages / iStock / Getty Images Plus

Researchers with Ohio State University, in Columbus, gave an oral presentation on “MMP20 May Initiate Enamel Formation via Basement Membrane Degradation,” during the 96th General Session of the International Association for Dental Research (IADR), held in conjunction with the IADR Pan European Regional (PER) Congress in London, England.

In the study, investigators studied whether Matrix metalloproteinase-20 (MMP-20) is capable of cleaving basement membrane proteins and if its temporal expression pattern is consistent with degradation of the basement membrane. MMP-20 expression is restricted to teeth and its malfunction causes amelogenesis imperfecta.

The results show that MMP20 expression was restricted to ameloblasts of the enamel organ and odontoblast of the pulp organ, and that MMP20 is expressed prior to basement membrane degradation. The basement membrane persisted in mice that had their tissue lining destroyed, but was degraded prematurely in MMP20 overexpressing mice, according to the study.

Add a Comment

Your email address will not be published. Required fields are marked *

Premier Dental & ADHA Announce Winners of ‘What Inspires You?’ Video Contest

PLYMOUTH MEETING, PA (August 16, 2018) – In partnership with the...

What Can the Herpesvirus Teach Us About Oral Inflammation?

A $2 million grant from the National Institutes of Health will...

OSAP Hires Michelle Lee as Executive Director

Michelle Lee, CPC, has joined OSAP as executive director. Lee comes...

Leslie E. Grant, DDS, MSPA, Presented with Lucy Hobbs Taylor Award

The American Association of Women Dentists (AAWD) has awarded Leslie E....

LANAP and LAPIP Protocols: Laser Gum Disease Protocols

Over 50% of US adults have gum disease.  Offer your patients...

IRIS HD USB 3.0 Intraoral Camera

Experience the Clarity in High Definition The new IRIS HD USB...

A New Adhesive/Primer Ideal for Indirect Restorations

At BISCO, adhesion is our passion. BISCO prides itself on developing...

KDZ Bruxer® Aesthetic

Bring the strength of full-contour zirconia into the facial zone with...