MMP20 May Initiate Enamel Formation via Basement Membrane Degradation

DragonImages / iStock / Getty Images Plus

Researchers with Ohio State University, in Columbus, gave an oral presentation on “MMP20 May Initiate Enamel Formation via Basement Membrane Degradation,” during the 96th General Session of the International Association for Dental Research (IADR), held in conjunction with the IADR Pan European Regional (PER) Congress in London, England.

In the study, investigators studied whether Matrix metalloproteinase-20 (MMP-20) is capable of cleaving basement membrane proteins and if its temporal expression pattern is consistent with degradation of the basement membrane. MMP-20 expression is restricted to teeth and its malfunction causes amelogenesis imperfecta.

The results show that MMP20 expression was restricted to ameloblasts of the enamel organ and odontoblast of the pulp organ, and that MMP20 is expressed prior to basement membrane degradation. The basement membrane persisted in mice that had their tissue lining destroyed, but was degraded prematurely in MMP20 overexpressing mice, according to the study.

Add a Comment

Your email address will not be published. Required fields are marked *

ADA Foundation Awards $120,000 in Funding to Eight Organizations 

 The ADA Foundation has awarded a total of $120,000 in funding...

A child smiling
CDC Cautions That Kids Are Using Too Much Toothpaste

Almost 40% or children between the ages of 3 and 6...

Jordan Baugh Joins American Dental Association

The American Dental Association (ADA) has named Jordan Baugh as its...

Study Examines Oral Health and Frailty

Researchers with the Department of Dentistry and Oral Surgery at Hyogo...

DentiMax Inc Complete Cloud Software Empowers Dentists

DentiMax Inc offers a complete, all-in-one, practice management and imaging cloud...

VIZ Intraoral Scanner
VIZ Intraoral Scanner from Adin Digital

The VIZ Intraoral Scanner from Adin Digital combines innovative imaging technologies,...

Sunset Dental Lab
Combination Partial from Sunset Dental Lab

Many patients who need a partial denture complain about the unsightly...

Etch e1
Etch e1 from

The product, e1, manufactured by is a 37% phosphoric acid etching...