fbpx
A peer-reviewed journal that offers evidence-based clinical information and continuing education for dentists.

Investigators Find How Teeth Sense Cold

Researchers at Howard Hughes Medical Institute in Maryland have determined the ion channel, TRPC5, acts as a cold sensor in teeth.

0

Researchers at Howard Hughes Medical Institute in Maryland have determined the ion channel, TRPC5, acts as a cold sensor in teeth. This may serve as a new drug target when treating dentinal hypersensitivity.

This discovery spanned more than a decade as investigators traced places throughout the body where tissues sense cold to pinpoint how TRPC5 cold-sensing ability came into play. According to the study, investigators recorded neural activity in mice as an ice-cold solution touched the tooth. Normal mice reacted to the cold solution, whereas mice lacking TRPC5 or in teeth treated with a chemical that blocked the ion channel did not experience nerve activity. 

The study, “Odontoblast TRPC5 Channels Signal Cold Pain in Teeth,” was published in Science Advances.

Leave A Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy

SAVE BIG ON CE BEFORE 2025!

:
:
:
Coupon has expired

Promotional Period: 12/14/24 – 12/31/24

Get Special CE Savings!