NYU Researcher Receives Grant to Study Oral Health in Those With Down Syndrome

Rodrigo Lacruz, PhD, MSc, a molecular pathobiology professor at New York University (NYU) College of Dentistry, secured a $1.5 million grant from the National Institute of Dental and Craniofacial Research and the National Institute of Health’s INCLUDE project. The 5-year grant supports his study on molecular aspects of salivary gland and tooth enamel formation in individuals with Down syndrome. Lacruz, who investigates oral health issues among individuals with genetic disorders, previously received a $2.3 million grant to explore mitochondria’s role in enamel formation. Down syndrome often causes oral health problems, such as low saliva production and weak tooth enamel. Understanding these concerns on a molecular level remains elusive. This research focuses on gene RCAN1 and protein calcineurin, aiming to clarify their roles in saliva production and enamel formation using mouse models. Click here to read more.