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Strategies for Managing Periodontal Disease

An understanding of periodontal disease phenotypes will help oral health professionals tailor highly personalized treatment plans.

An understanding of periodontal disease phenotypes will help oral health professionals tailor highly personalized treatment plans
This course was published in the August 2018 issue and expires August 2021. The authors have no commercial conflicts of interest to disclose. This 2 credit hour self-study activity is electronically mediated.


After reading this course, the participant should be able to:

  1. Explain the concept of clinical phenotypes of periodontal disease.
  2. Discuss the etiology of gingivitis and periodontitis.
  3. Identify methods to help patients prevent periodontal disease.

After taking a thorough medical and dental history, the standard periodontal examination begins with the evaluation of clinical and radiographic signs and symptoms to determine the extent and severity of gingival and periodontal tissue damage.1,2 The presentation of periodontal disease, or clinical phenotype, follows clinical features of inflammation, redness, edema, bleeding on probing, and loss of periodontal attachment, as evidenced by probing depth, attachment level, gingival recession and alveolar bone loss.3 These recognized techniques are insufficient alone, however, as they often result in a diagnosis that is inconsistently reproduced, as well as an unreliable treatment outcome prognosis.4 The limited success of prognosis in periodontal disease progression in some patients is due to the clinical appearance not reflecting the biology at the biofilm-gingival interface.4 Periodontitis is multifactorial, and disease phenotype is expressed based on complex interactions of the plaque biofilm with the host immune-inflammatory response, resulting in changes in homeostasis of osseous and gingival tissues.5–7

Understanding the biology underlying various clinical phenotypes of periodontal disease should aid oral health professionals in establishing a periodontal prognosis and developing novel and highly personalized treatment plans.8

Current periodontal classifications have been updated to alleviate the clinical challenge of classifying periodontal conditions primarily based on attachment loss and microbiological test results, which can sometimes be ambiguous.9 Baelum and Lopez10 stated that “periodontal disease is a syndrome that comes in all sizes,” suggesting there are no clear demarcations between health and disease, or between conditions. Rather, it appears it is the initial and early host-inflammatory and immune responses to the bacterial assault that seem to favor the emergence of classic periopathogens and, in turn, determine periodontal disease development or progression.8

Recent evidence-based concepts suggest that inflammation is critical in conditions such as cardiovascular disease and Alzheimer’s disease, which previously have not been considered inflammatory.11 Today, inflammatory mechanisms are recognized as integral to the development and progression of most chronic diseases of aging.8,11–13 Environmental and genetic variations interact and account for differences in inflammation among individuals.11 While inflammation in the body is actively resolved by protective mechanisms that help to restore homeostasis, there are ways to support these processes.11,14 Although genes do not change, gene expression in specific tissues can evolve significantly throughout life through factors such as diet, stress and bacterial accumulations.15 Abdominal and visceral fat accumulations increase the inflammatory burden on the body,12 and overexpression of inflammation may be one of the key aspects of aging that influences and links various diseases in individuals.14,16

Kornman17 and others assert that chronic adult periodontitis is a bacterially induced chronic inflammatory disease that destroys the attachment apparatus supporting the teeth.5 Experimental evidence implicates plaque as the primary etiological factor for initiating periodontitis. Concomitantly, specific periopathogenic bacteria and immune-inflammatory mechanisms are involved in complex interactions.18

In the model of periodontal pathogenesis including this concept, pathogens activate an immune-inflammatory mechanism. This adversely affects the host control of the bacterial challenge, as well as the remodeling of osseous and gingival structures.17 Various environmental and genetic factors are changing the clinical appearance of periodontal disease in a given patient.17

Any clinical phenotype of periodontal disease can be broken down into respective subclinical components to provide a biologic systems model for classifying periodontal disease in humans (Figure 1).19 In disease, the biologic systems model incorporate all components that contribute to the final clinical presentation of disease.4,8 The outermost factors are the individual exposures of each subject, including the characteristics of his or her oral biofilm (i.e., the type of bacterial infection), as well as the presence of medical conditions (e.g., diabetes or obesity) and environmental influences (e.g., smoking). The subject-level component interacts with the genetic background, as the evidence suggests that specific gene polymorphisms are associated with periodontal disease,14 influencing the host response to infections.20

FIGURE 1. Biologic system model. Modified from: Offenbacher S, Barros SP,
Singer RE, Moss K, Williams RC, Beck JD. Periodontal disease at the biofilmgingival
J Periodontol. 2007;78:1911–1925.


In more than half a century of worldwide translational research and clinical studies, it has been established that effective and persistent removal of dental plaque is conditional to achievement and maintenance of oral health.21 According to the nonspecific plaque hypothesis, any reduction of the noxious load of plaque and its bacterial byproducts adjacent to gingiva will reduce gingivitis — the precursor to periodontitis. As supragingival plaque matures and progresses to subgingival plaque, any decrease in bacterial deposits will prevent gingivitis. The maintenance of noninflamed gingiva will help prevent chronic periodontitis. As the dental biofilm accumulates, oral hygiene helps control the amount of bacterial deposits on the dental structures and their apical migration. This constitutes primary gingivitis prevention.22

While it is generally recommended that patients remove dental plaque by brushing their teeth at least twice per day, it is evident from epidemiological and clinical studies that home-based mechanical oral hygiene procedures, such as brushing and flossing performed by most patients, are not sufficient to reduce plaque buildup and prevent disease.23–25 Although no statistically significant difference was found between power and manual toothbrushes,26 rotating and oscillating brushes were shown to reduce short- and long-term biofilm formation and gingival disease. Another advantage to power toothbrushes is the timer function that indicates length of brushing, helping patients reach the recommended two minutes. Overall, patients tend to use less pressure when brushing with a power toothbrush due to pressure sensors within the brush; this reduces trauma to the buccal gingiva, possibly reducing the risk of recession.27

According to research, bisbiguanide compounds, such as chlorhexidine gluconate and alexidine, are the most effective mouthrinse ingredients used to inhibit plaque formation, especially after mechanical removal of biofilm. Chlorhexidine has shown less plaque inhibition when included in dentifrices. This is probably due to flavor, detergent and blood inactivating the antimicrobial inhibitory pathways.28,29 Mouthrinses containing essential oils (thymol, menthol, eucalyptol and methyl salicylate), as well as those with cetylpyridinium chloride, have been shown to be effective in decreasing supragingival plaque and gingivitis.30,31 While not an antiseptic, mouthrinse containing delmopinol helps to prevent plaque from adhering to the teeth and gingiva.32

Some oral hygiene agents have side effects, however. Chlorhexidine can cause external staining of teeth.33 Pyrophosphates, flavorings and detergents, such as sodium lauryl sulfate, have been implicated as possible causative factors in specific mucosal and gingival hypersensitivities (e.g., aphthous ulcers, stomatitis, cheilitis, burning mouth syndrome and oral mucosal desquamation).33–35 Oral health professionals should recommend alternatives in these cases.

Prevention is based on the principle that the greatest effect is achieved where the greatest risk is identified.36 Periodontal lesions in patients with increased risk for periodontal disease are located interdentally rather than buccally or lingually, as cleaning of tooth surfaces is facilitated by the ability of the toothbrush to access the location. The anatomic interproximal gingival structure under the contact point of adjacent teeth, or the col, is not keratinized. It is also the area of maximum plaque accumulation and the most difficult to access.

While patients may have an interdental aid preference,37 factors such as gingival biotype, anatomy of the embrasure between teeth, tooth location in the dental arch and alignment, and patient’s dexterity, motivation and compliance, should be considered when providing interproximal oral hygiene instructions.38–41 Most studies show improvement of plaque scores when comparing patients using interproximal brushes with the use of floss.39 Two of three studies showed that the regular use of interdental brushes reduced pocket depth more than the use of floss in patients with periodontitis.18,42 One study compared interdental brushes with wood sticks and found that interproximal brushes were more effective in plaque removal (Figure 2).42 The most effective cleaning is achieved when the largest brush size that fits into the embrasure is used. As such, patients should have various brush sizes available to use for anterior and posterior areas. In areas of dental crowding and in young patients where the papillae fill out the embrasures, dental floss is suitable for interdental oral hygiene.23

Periodontal Treatment
FIGURE 2. When using an interdental brush in the posterior region, if the buccal embrasure is too narrow to fit the brush head through comfortably, a lingual approach is recommended.
Periodontal Management
FIGURE 3. Some oral health
professionals recommend adding 1⁄2 tsp of bleach as an antimicrobial to a full tank filled with warm water when using interproximal
irrigation devices.


Three studies found a reduction in inflammatory response when adding oral irrigation to a self-care regimen (Figure 3).29,42,43 In two studies, pocket depth reduction was also achieved.29,43 Accessories for oral irrigator devices facilitate up to 90% penetration of the irrigation liquid into a 6-mm pocket when the tip is inserted 1 mm subgingivally.44 Oral irrigation potentially induces bacteremia when compared with toothbrushing,45,46 interdental flossing,47,48 scaling and root planing,49 and even chewing50 because the gingiva is subject to considerable force during supragingival irrigation. For healthy patients, however, the literature attests to the safety of oral irrigation.

The clinical effects of oral irrigation are multifold. When used daily supragingivally, oral irrigation alters the composition of periodontal pathogens and their interaction with the host response in patients with gingivitis.43 The water pulsation may reduce inflammation independently from biofilm debridement.51 In addition, flushing out macroscopic debris and bacterial components in pathogenic floating plaque interferes with the maturation of the plaque biofilm and may stimulate the host immune response.42 The discrepancy between the positive effect of irrigation in reducing gingival inflammation and statistical significance of its effect in the literature may be related to research using an all-or-nothing grading system, in which plaque thickness is not considered.29,52

In conclusion, the research asserts that one single oral hygiene instruction by a dental professional can positively affect the prognosis of periodontitis in a patient for approximately six months. This is in congruence with the three- to six-month recare interval.23,27,36 This confirms the importance of patient education by oral health professionals in the prevention of periodontal disease.


The authors would like to thank Christopher Aloise, BA; Marc Rabins, BA, BS; and Samuel Rabins for their help with this manuscript.


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From Decisions in Dentistry. August 2018;4(8):40–43.

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