A peer-reviewed journal that offers evidence-based clinical information and continuing education for dentists.

Commonly Used Medications May Negatively Interact With New COVID-19 Pills


The use of statins, blood thinners, and antidepressants is ubiquitous across the United States; however, these drugs may pose risks when taken in conjunction with the new antiviral medications that treat COVID-19. The COVID-19 pills—Paxlovid by Pfizer and Molnupiravir by Merck— may cause serious side effects when used with these common medications. Paxlovid is contraindicated among those with kidney or liver disease. Other medications that may interact with the COVID-19 pills include immunosuppressants, steroids, and those that treat the following:

  • Seizures
  • Heart arrhythmia
  • High cholesterol
  • High blood pressure
  • Anxiety
  • Human immunodeficiency virus
  • Erectile dysfunction

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