Study Shows That Growth Factor Enhances Cells’ Ability to Regenerate Dentin-Pulp


Researchers at Shanghai Jiao Tong University’s School of Medicine are investigating a type of platelet-derived growth factor, PDGF-BB, that enhances cells’ ability to prompt dentin-pulp regeneration. The study, “The Effects of PDGF-BB on Human Dental Pulp Stem Cells Mediated Dentin-Pulp Complex Regeneration,” was published in Stem Cells Translational Medicine.

Investigators report that when scaffolds containing engineered cells were implanted in mice for 12 weeks, the subjects treated using scaffolds seeded with PDGF-BB cells outperformed the other test groups. This group generated more dentin-like mineralized tissue that showed positive staining for the dentin sialophospho protein, similar to dentinal tissue. In addition, it was surrounded by highly vascularized, dental pulp-like connective tissue. The data also demonstrate that PDGF-BB significantly increased the proliferation of the human dental pulp stem cells (hDPSCs). According to the authors, the findings represent a significant step toward optimal application of PDGF-BB for improving hDPSCs-mediated, dentin-pulp complex regeneration.

From Decisions in Dentistry. February 2018;4(2):8.

Add a Comment

Your email address will not be published. Required fields are marked *

Stony Brook Researchers Receive NIH Grants

The National Institutes of Health (NIH) National Institute of Dental and...

Kettenbach LP Acquires Airway Metrics

Huntington Beach, CA — Management from Kettenbach LP and Airway Metrics LLC...

Minnesota Dental Association Releases Opioid Support Materials

MINNEAPOLIS – The Minnesota Dental Association (MDA) has published a brochure...

Crosstex Acquires Vista Research Group

Hauppauge, NY – Crosstex International Inc has acquired Vista Research Group...

OrVance Ortho Dots
OrVance Launches the First Globally Compliant Orthodontic Wax

GRAND RAPIDS, MICHIGAN – January 10, 2019 – OrVance LLC, a...

KaVo Kerr OptiBond
KaVo Kerr Announces OptiBond eXTRa Universal Bonding Agent

TKaVo Kerr is excited to introduce OptiBond™ eXTRa Universal, a new...

Light patent
Orascoptic Granted U.S. Patent for Optical Design Used in All Headlights

Orascoptic was recently granted a U.S. patent for the optical design...

ClinPix Dental Camera
CliniPix 123-EZ Dental Camera

CliniPix 123-EZ camera small and light, enables the dentist or staff...