Researchers at Shanghai Jiao Tong University’s School of Medicine are investigating a type of platelet-derived growth factor, PDGF-BB, that enhances cells’ ability to prompt dentin-pulp regeneration. The study, “The Effects of PDGF-BB on Human Dental Pulp Stem Cells Mediated Dentin-Pulp Complex Regeneration,” was published in Stem Cells Translational Medicine.
Investigators report that when scaffolds containing engineered cells were implanted in mice for 12 weeks, the subjects treated using scaffolds seeded with PDGF-BB cells outperformed the other test groups. This group generated more dentin-like mineralized tissue that showed positive staining for the dentin sialophospho protein, similar to dentinal tissue. In addition, it was surrounded by highly vascularized, dental pulp-like connective tissue. The data also demonstrate that PDGF-BB significantly increased the proliferation of the human dental pulp stem cells (hDPSCs). According to the authors, the findings represent a significant step toward optimal application of PDGF-BB for improving hDPSCs-mediated, dentin-pulp complex regeneration.
From Decisions in Dentistry. February 2018;4(2):8.