Gingival Cancer Overview for General Practitioners

Early diagnosis and staging of this rare disease is critical, because lesions often mimic other inflammatory periodontal conditions
This course was published in the September 2017 issue and expires September 2020. The author has no commercial conflicts of interest to disclose. This 2 credit hour self-study activity is electronically mediated.


After reading this course, the participant should be able to:

  1. Discuss the incidence of gingival squamous cell carcinoma (SCC), recurrence, and the characteristics that make diagnosis challenging.
  2. Explain the general practitioner’s role in identifying and treating patients with gingival SCC.
  3. List imaging modalities and treatments used in managing gingival SCC.

Gingival squamous cell carcinoma (SCC) is a rare disease that accounts for approximately 10% of SCC encountered within the oral cavity. While its etiology is unknown, it is commonly thought to arise from a preexisting leukoplakia or erythroplakia found on the gingiva. The average age of the patient at initial presentation is 60 to 70 years, and this condition often develops in those once considered to be at low risk for oral SCC, including nonsmokers or individuals who consume little or no alcohol.1–4 Compared to the established role of human papillomavirus (HPV) and its etiology and prognosis with oropharyngeal SCC, HPV and its association to oral cavity SCC (including the gingiva) have not been proven, with an overall incidence reported between 4% and 22%.5,6

An initial diagnosis of gingival SCC can be difficult to establish, as early lesions often present with an appearance similar to inflammatory periodontal conditions or local tissue trauma. Consequently, any of the following signs or symptoms should be considered with a high degree of suspicion: red/white lesions, ulceration, loose teeth, swelling, pain or a nonhealing extraction socket. Commonly, masses identified under an ill-fitting denture are attributed to inflammatory conditions (such as an epulis fissuratum), when, in reality, they are SCC. Granular-appearing SCC tissue near a dental endosseous implant can easily be misdiagnosed as peri-implantitis (Figure 1 and Figure 2). Tumors at more advanced stages will present with a mass or lower lip paresthesia, especially if the inferior alveolar nerve is involved. As a rule, any gingival lesion presenting with the previously described signs and symptoms that has not resolved within three to four weeks should be biopsied.7–10

The use of imaging is important to identify bone invasion, as this will affect prognosis. Plain film imaging, such as orthopantomogram and periapical dental films, can be used for initial evaluation, but are considered low-sensitivity tests, as they require at least 30% to 50% bone demineralization to demonstrate bone loss or changes. Computed tomography (CT scans) and magnetic resonance imaging (MRI) are considered to be first-line imaging modalities in the preoperative management of gingival SCC.8 These tests can provide important details regarding overlying soft tissue, extent of bone involvement and regional nodal metastases. A high-resolution, fine-sliced CT scan (1 mm slices) can also be utilized to provide accurate three-dimensional models for use in virtual surgical planning and advanced reconstructive techniques (Figure 3).11,12 Besides CT, clinicians will also find MRI helpful due to its improved sensitivity and specificity for identifying bone marrow involvement and tumor infiltration of the inferior alveolar nerve. Positron emission tomography is a newer (and more costly) imaging technology that identifies the tumor by its metabolic uptake of a radioactive glucose molecule. This modality is generally useful in the evaluation of regional (cervical node metastases) and distant disease (e.g., lung metastases) in advanced stage tumors.8

FIGURE 1. Squamous cell carcinoma of the gingiva adjacent to teeth #27 and #28.

FIGURE 2. Squamous cell carcinoma surrounding dental implants that was
mistaken for peri-implantitis.

Initial tumor staging requires a thorough clinical and radiographic examination. Tumors are generally staged using the designated tumor, node, metastasis (TNM) American Joint Committee on Cancer (AJCC) staging system.13 Difficulty with this classification occurs in relationship to advanced size (T4) and the specific gingival subsite. Alveolar bone invasion can occur early secondary to the thin layer (2 to 3 mm) of overlying attached gingiva. Marrow invasion is generally believed to constitute a more aggressive tumor with worse prognosis — however, many clinicians have questioned if tumor infiltration in the alveolar marrow bone meets this definition. Gomez et al1 reported on a series of 83 gingival tumors, and found that bone invasion is an early event and not necessarily an indication of advanced stage disease. Based upon numerous studies, the AJCC has modified its staging to report that superficial/alveolar bone invasion does not result in T4a (bone invasion) upstaging because there is inconclusive evidence as to worse prognosis with such alveolar bone involvement.

FIGURE 3. Virtual surgical plan and three-dimensional reconstruction of mandibular
defect using a fibula vascularized flap secondary to a gingival carcinoma requiring
segmental mandibular resection.

This debate can be further expanded to the situation in which the patient presents with a positive cancer biopsy in the site of a recent dental extraction. Tumor invasion is generally thought to occur by two methods. In an edentulous individual, the overlying gingiva is involved and invasion occurs through cortical perforations and channels within the bone. In the dentate patient, invasion often occurs via the periodontal ligament and tracks into the basal bone.14 Evaluating bone invasion following a recent extraction can be challenging for the treating surgeon. It can be difficult to assess if the tooth was mobile secondary to frank bone loss from tumor bone erosion, or if it was secondary to inflammatory periodontitis.8,9,15 Often, the tooth socket has been curetted or treated with bone graft materials, and tumor seeding into the basal bone at the apex of the socket is suspected. Despite this dilemma, prognosis regarding disease recurrence and overall survival has not been established, as there is evidence in the literature in favor of, and against, this hypothesis. As a guide for the general practitioner, if a loose tooth is identified within a gingival mass, it is best not to extract the associated tooth, as this will allow the treating surgeon to assess not only for true bone invasion, but also evaluate the extent of the tumor in the surrounding soft tissue.


Primary management of gingival SCC involves surgical resection of the associated tumor within the maxilla or mandible.2–4,8 Radiation for this subsite within the oral cavity is usually reserved for the adjuvant setting, based upon final pathologic evaluation of the resected specimen. This is especially true in early stage disease, where single modality therapy can be utilized and avoiding radiation eliminates the risk of osteoradionecrosis (ORN).16–18 Advanced stage disease requires surgery, followed by adjuvant radiotherapy or combined chemoradiotherapy. Prognosis is impacted by the ability to attain a negative surgical margin. Surgical resection involves taking a 1 cm bone and soft tissue margin beyond the visualized tumor and, in the case of a dentate patient, extending the resection to at least one tooth on either side of the tumor. A tumor within the maxillary alveolus requires at least a partial maxillectomy, often with extension into the maxillary sinus or floor of the nose.

Mandibular resection involves at least removal of the dentoalveolar segment (marginal mandibulectomy) or a composite resection of the entire segment, including the inferior border of mandible (segmental mandibulectomy) in cases involving medullary bone invasion.2–4,8 Other considerations for segmental mandibulectomy include direct invasion of the inferior alveolar nerve, and in cases in which minimal mandibular bone height or thickness will remain, resulting in high risk for postoperative mandibular fracture.19 With smaller defects, reconstruction can be achieved with local flaps and dental prosthesis (denture/obturator), while larger defects will require formal bone and soft tissue vascularized flap reconstruction.8,20,21 This method will provide the framework for facial profile, bone continuity and the possibility of implant-retained dental support. (Figure 4 and Figure 5). Free bone grafting becomes more difficult in larger defects (> 4 to > 5 cm) or for patients who require adjuvant radiation therapy.8 Dental rehabilitation of these patients requires a team approach involving coordinated care between the reconstructive surgeon and maxillofacial prosthodontist.

FIGURE 4. Postoperative computed tomography scan of integrated fibula flap for a mandibular reconstruction. Mandibular symmetry is achieved using computer planning.

In terms of progression free survival and overall survival, one of the most important negative prognostic factors is the presence of regional cervical nodal metastasis. Historically, with respect to risk of occult nodal metastasis (i.e., disease not detected on imaging or clinical exam), SCC of the gingiva was thought to be less aggressive; the decision to perform neck dissection was generally reserved for patients presenting with clinically positive disease (N+) or with advanced size cancers (e.g., T3 to T4 size). Recent review series have reported the incidence of occult nodal disease to range from 11% to 27% and 10% to 31% within the maxilla and mandible, respectively, with a recommendation from many clinicians to consider elective neck dissection in patients presenting with early stage gingival SCC (T1 to T2 size).1–4,10,13,15,22

FIGURE 5. Dental implants placed into a mandibular fibula flap reconstruction for a
previously treated squamous cell carcinoma of the anterior mandibular gingiva.

Radiation therapy in the adjuvant setting is generally reserved for advanced stage cancers to improve locoregional control. Newer techniques using intensity-modulated radiotherapy and proton therapy have allowed for more focused techniques, while minimizing the side effects of xerostomia and dysphagia. Independent factors, such as perineural invasion, have been shown to be risk factors for locoregional recurrence and consideration for adjuvant radiotherapy. Two large randomized trials demonstrated the benefit of combined chemoradiotherapy (radiation and cisplatin) for patients with pathologic features that include positive tumor margins, multiple positive lymph nodes and extranodal extension of disease.23,24 Newer medical therapies involve the use of epidermal growth factor receptor blockers (e.g., cetuximab) and immune checkpoint inhibitors (such as nivolumab) for patients who have developed recurrence following failed combined surgery and chemoradiotherapy.25

Surveillance is important to identify recurrent disease, with the hopes of early detection and salvage. Most recurrences of gingival SCC occur within the first two years of therapy and surveillance is most aggressive during this time period, with routine evaluations every two months. Local recurrences that occur early (within the first 10 months of treatment) can generally be salvaged with surgery, while early regional failures often carry a poorer prognosis — especially in the previously dissected neck.26


The general practitioner’s role during the postoperative phase is extremely important, not only as a second pair of eyes for tumor surveillance, but also in helping maintain the patient’s oral health. Patients may require preradiation dental restorations or extractions to help prevent ORN. Fluoride trays and routine dental prophylaxis will be required to help prevent radiation caries, as these patients are at high risk secondary to postradiation xerostomia. The incidence of ORN is reported to be between 5% and 15%, and the role of hyperbaric oxygen therapy has not been established in the prevention or management of this disease. Newer theories as to the cause of ORN have been hypothesized (such as fibroatrophic theory), and the use of tocopherol (vitamin E) and pentoxifylline have become more common in the management of patients requiring dental extraction postradiation and in the early treatment of ORN.16–18


As noted, gingival SCC is an uncommon cancer within the oral cavity that may easily be mistaken for periodontal disease or local tissue trauma. Many studies regarding the treatment are retrospective or based upon the management of other oral cavity SCC subsites. Aggressive surgical therapy that addresses both the management of the primary site and neck is indicated to achieve optimal locoregional control. The general dental practitioner can — and should — play a crucial role in the early detection and post-therapy management of this disease.


  1. Gomez D, Faucher A, Picot V, et al. Outcome of squamous cell carcinoma of the gingiva; a follow-up study of 83 cases. J Craniomaxillofac Surg. 2000;28:331–335.
  2. Shingaki S, Nomura T, Takada M, Kobayashi T, Suzuki I, Nakajima T. Squamous cell carcinomas of the mandibular alveolus: analysis of prognostic factors. Oncology. 2002;62:17–24.
  3. Bark R, Mercke C, Munck-Wikland E, Wisniewski N, Hammarstedt-Nordenvall L. Cancer of the gingiva. Eur Arch Otorhinolaryngol. 2016;273:1335–1345.
  4. Lubek J, El-Hakim M, Salama AR, Liu X, Ord RA. Gingival carcinoma; retrospective analysis of 72 patients and indications for elective neck dissection. Br J Oral Maxillofac Surg. 2011;49:182–185.
  5. Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M. Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012;6(Suppl 1):S104–S120.
  6. Herrero R, Castellsagué X, Pawlita M, et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst. 2003;95:1772–1783.
  7. Bharanidharan R, Dineshkumar T, Raghavendhar K, Kumar AR. Squamous cell carcinoma of the gingiva: a diagnostic enigma. J Oral Maxillofac Pathol. 2015;19:267.
  8. Lubek JE, Magliocca KR. Evaluation of the bone margin in oral squamous cell carcinoma. Oral Maxillofac Surg Clin North Am. May 24, 2017. Epub ahead of print.
  9. Yamagata K, Ito H, Onizawa K, Yamatoji M, Yanagawa T, Bukawa H. Prognosis for gingival carcinoma with a delayed diagnosis after dental extraction. J Oral Maxillofac Surg. 2013;71:2189–2194.
  10. Muñoz Guerra MF, Naval Gías L, Campo FR, Pérez JS. Marginal and segmental mandibulectomy in patients with oral cancer: a statistical analysis of 106 cases. J Oral Maxillofac Surg. 2003;61:1289–1296.
  11. Monaco C, Stranix JT, Avraham T, et al. Evolution of surgical techniques for mandibular reconstruction using free fibula flaps: the next generation. Head Neck. 2016;38(Suppl 1):E2066–E2073.
  12. Rodby KA, Turin S, Jacobs RJ, et al. Advances in oncologic head and neck reconstruction: systematic review and future considerations of virtual surgical planning and computer aided design/computer aided modeling. J Plast Reconstr Aesthet Surg. 2014;67:1171–1185.
  13. Amin MB, Edge S, Greene F, et al, eds. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer; 2017.
  14. McGregor AD, MacDonald DG. Routes of entry of squamous cell carcinoma to the mandible. Head Neck Surg. 1988;10:294–301.
  15. Overholt SM, Eicher SA, Wolf P, Weber RS. Prognostic factors affecting outcome in lower gingival carcinoma. Laryngoscope. 1996;106:1335–1339.
  16. Annane D, Depondt J, Aubert P, et al. Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled double-blind trial from the ORN96 study group. J Clin Oncol. 2004;22:4893–4900.
  17. Delanian S, Chatel C, Porcher R, Depondt J, Lefaix JL. Complete restoration of refractory mandibular osteonecrosis by prolonged treatment with a pentoxifylline tocopherol clodronate combination (PENTOCLO): a phase II trial. Int J Radiat Oncol Biol Phys. 2011;180:832–839.
  18. Lubek JE, Hancock MK, Strome SE. What is the value of hyperbaric oxygen therapy in management of osteoradionecrosis of the head and neck? Laryngoscope. 2013;123:555–556.
  19. Barttelbort SW, Bahn SL, Ariyan S. Rim mandibulectomy for cancer of the oral cavity. Am J Surg. 1987;154:423–428.
  20. Chigurapati R, Aloor N, Salas R, Schmidt BL. Quality of life after maxillectomy and prosthetic obturator rehabilitation. J Oral Maxillofac Surg. 2013;71:1471–1478.
  21. Brown JS, Rogers SN, McNally DN, Boyle M. A modified classification for the maxillectomy defect. Head Neck. 2000;22:17–26.
  22. Montes DM, Carlson ER, Fernandes R, et al. Oral maxillary squamous carcinoma: an indication for neck dissection in the clinically negative neck. Head Neck. 2011;33:1581–1585.
  23. Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945–1952.
  24. Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937–1944.
  25. Ferris RL, Blumenschein G Jr., Fayette J, et al. Nivolumab for recurrent squamous cell carcinoma of the head and neck. N Engl J Med. 2016;375:1856–1867.
  26. Liao CT, Chang JT, Wang HM, et al. Salvage therapy in relapsed squamous cell carcinoma of the oral cavity: how and when? Cancer. 2008;112:94–103.


From Decisions in Dentistry. September 2017;3(9):32–35.

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