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Understanding the Oral Manifestations of Khat

Cultural competency training will help oral health professionals provide appropriate care and referrals when treating patients who use khat.

This course was published in the September 2021 issue and expires September 2024. The authors have no commercial conflicts of interest to disclose. This 2 credit hour self-study activity is electronically mediated.



After reading this course, the participant should be able to:

  1. Discuss khat chewing as a cultural tradition, its prevalence, and the role of cultural competency training in treating the oral and systemic effects of its use.
  2. List clinical strategies and concerns when caring for this patient population.
  3. Describe the potential oral health consequences of khat use.

Oral health professionals work in a global society where opportunities exist to acquire cultural knowledge through cross-cultural encounters and cultural competency training. Supported by the understanding that variability exists within cultures as a complex whole, cultural awareness leads to care modifications that recognize and integrate patients’ traditional beliefs and practices.1–3 One facet that deserves special attention concerns patients’ cultural habits. For example, it is estimated that more than 20 million people worldwide chew khat (Catha edulis),4 which is cultivated and consumed as part of social traditions in Ethiopia, Kenya, Yemen, Somalia, South Africa, Saudi Arabia and Madagascar.5 Recently, khat has traveled with people to Europe, Norway, Great Britain, North America and Australia. Globally, Yemeni people are one of the largest consumers of khat, with the World Health Organization estimating that 70% to 90% of men, 30% to 50% of women, and 25% of children in Yemen chew khat daily.6,7

People living in the United States who are from other countries may continue to use behavioral practices customary to their country of origin. While there are no reliable estimates of prevalence in the United States, khat use is highest in cities with corresponding immigrant populations, such as Boston, Dallas, Detroit, Los Angeles, Minneapolis, New York and Washington, D.C.8 Using customary practices helps the individual maintain a feeling of connection to his or her traditions.2 While chewing khat leaves is a common worldwide endemic, social and cultural habit, it is not an oral hygiene aid. 

Khat, also known as qat, kat, miraa, qaad or jaad, is a flowering evergreen plant that primarily grows in East Africa and the Arabian Peninsula (Figure 1).8–10 There are approximately 44 types of khat, with taste variations depending on the tannic acid content. Mature leaves have a bitter taste and are fragrant, while young leaves are slightly sweet.6 Users tuck fresh leaves into the buccal mucosa and replenish leaves often so juices can be extracted and swallowed (Figure 2).11 Dried khat is used to make tea, chewable paste for recreational use, and can be smoked or sprinkled onto food as a powder.8 It is chewed as a pastime or during traditional celebrations. Khat is often used for its stimulant effect, as chewing it reduces fatigue and brings amphetamine-like feelings of euphoria and alertness.5,8 Many khat chewers report feeling happy, alert and energetic.12 


Catha edulis leaves contain two main stimulants of the central nervous system (CNS), cathinone and cathine.8,13,14 Cathinone (alpha aminopriopiophenone) is structurally similar to d-amphetamine and is a sympathomimetic, amphetamine-like substance that stimulates the autonomic sympathetic nervous system. Cathine (d-nor pseudoephedrine) acts as an CNS stimulant, with cathine being 10 times less potent than cathinone.8,14 Other compounds in khat include alkaloids (over 62 types), carbohydrates, tannins, flavonoids, terpenoids, sterols, glycosides, vitamin C and amino acids.15 Once consumed, the effects can last from 90 minutes to three hours, but with prolonged use effects may last up to 24 hours.8 After chewing khat, the individual may experience depression, irritability, loss of appetite and difficulty sleeping.16 Khat is a naturally occurring plant and therefore may contain varied compound combinations and concentrations. It can have several temporary or short-term effects on the autonomic (peripheral) nervous system and CNS, depending on the amount the user ingests (Table 1).

FIGURE 1. Fresh khat leaves.
FIGURE 1. Fresh khat leaves.


Several studies have examined the long-term effects of khat, including a systematic review and meta-analysis that suggests it increases risk for heart failure, arrhythmia, myocardial infarction and stroke.17 Reported long-term exposure to the cathinone content increases heart rate and blood pressure, and has a vasoconstriction effect on the coronary vessels.11 Mean diastolic and systolic blood pressure in khat users is higher than nonusers; similarly, the heart rate of users is consistently higher than controls.17 In addition, khat has known be an independent risk factor for cardiovascular disease.18 

Users are also more likely to experience an increase in liver disease.12 Additionally, gastrointestinal disorders linked to khat include gastritis, chronic constipation and hemorrhoids.19 Specifically, khat can harm the gastrointestinal system by delaying intestinal absorption.20 

Its effects on mental health are associated with the amphetamine-like cathinone substance found in khat that releases serotonin.21 Adverse long-term psychiatric effects include dependence, tolerance, anxiety, depression and insomnia.8 When assessing a patient’s dependence status, the severity of dependence scale can prove helpful. Using this approach, one study found 31% of participants presented with khat dependence, and 38% exhibited continued use, even when experiencing adverse effects.22 Several studies on small samples of diverse user groups found psychological dependence was greater in those who used khat for longer than six hours a day. Reported withdrawal symptoms include depression, food cravings and fatigue.14,23,24


In general, khat can have detrimental oral health effects, such as periodontal disease, mucosal lesions and caries.25 In addition, users may demonstrate poor oral hygiene compared to nonusers, including a lack of regular toothbrushing and increased plaque accumulation.26 Khat chewing may also lead to increased probing depths, gingival bleeding, recession, clinical attachment loss and tooth loss.5,25,27 

FIGURE 2. Khat bolus in cheek.
FIGURE 2. Khat bolus in cheek.

Among users, the oral mucosa is thought to be the first point of absorption, and bolus sites often undergo mucosal changes in the form of keratotic white lesions and areas of frictional keratosis with severe corrugation. These lesions are caused by continuous and prolonged exposure to mechanical friction, as well as the chemical irritation caused by khat components.28 The prevalence of white oral lesions was found to be higher among users (33.3%) compared to nonusers (7.7%).29 

A high prevalence of oral ulcers and burning sensations has been observed in khat users.27 Chewing khat has also been associated with white to brown mucosal discoloration that is attributed to the chemical components of the plant. Specifically, high concentrations of melanin  in basal keratinocytes of tissue samples were found in chronic khat chewers.30 Surprisingly, the association between consuming khat and malignant oral lesions had no clear evidence implicating it as a risk factor for head and neck cancers.25 Considering an association between malignant oral lesions remains unclear, more research is needed. 

A study of Yemeni khat users found a greater incidence of tooth loss when compared to nonusers (2.5 to 2.1 for males, and 3.4 to 2.8 for females, respectively).31 As previously noted, research also relates chewing khat to caries. As a predisposing factor for caries, oral dryness was reported to occur 30 minutes after initiating a khat-chewing session.32 Additionally, researchers found users tend to consume an increased number of sugary beverages and sugar tablets to counteract the bitter taste.25 Khat can cause xerostomia due to its amphetamine-like effect or the fatigue of salivary glands due to continuous chewing.33 It has also been found to reduce salivary flow rates and pH levels — factors that could increase the incidence of caries.33

* Adapted from World Health Organization. Expert Committee on Drug Dependence. Assessment of Khat (Catha edulis Forsk).
* Adapted from World Health Organization. Expert Committee on Drug Dependence. Assessment of Khat (Catha edulis Forsk).6


When considering khat’s effects, several recommendations can be made for patient care. Patients’ vitals should be taken at each appointment, as research has demonstrated the link between khat chewing and elevated blood pressure and pulse. Moreover, oral health professionals should exercise caution when considering use of local anesthesia or nitrous oxide-oxygen sedation due to CNS effects and possible drug or health interactions. For example, khat has been shown to reduce the effects of local anesthetic drugs.34 Due to the possible simultaneous use of khat and dental medications, mitigation strategies to decrease the probability of adverse drug interactions should be established to ensure safe and effective care. 

Research findings indicate clinical drug interactions may also exist with antibacterial, antimalarial, antiplatelet and anesthetic drugs.34 Additionally, khat has been known to reduce the bioavailability of antibiotics, such as ampicillin, amoxicillin, cephradine, ciprofloxacin and tetracycline.34 Its use may also compromise the antimalarial activity of primaquine, and may reduce the bioavailability and antiplatelet aggregating properties of aspirin.34 

Dental professionals should conduct social assessments that encourage patients to provide information about behavioral habits, particularly cultural traditions.35 It is important to address patients’ cultural values specifically in the context of their healthcare by asking:

  • Is there anything I should know about your culture, beliefs or religious practices that would help me take better care of you? 
  • Do you have any dietary restrictions that we should consider as we develop a plan for nutritional counseling? 
  • What do you call your illness and what do you think caused it? 
  • Do any traditional healers advise you about your health?36

Since oral lesions are common in khat users, such defects should be well documented, explained to the patient, and referred for biopsy as needed. Due to the adverse effect of khat on periodontal health, clinicians should encourage regular dental hygiene and maintenance appointments, and consider shorter durations between visits. Recommendations can also be made to reduce the incidence of xerostomia and caries through the use of fluoride therapy and saliva substitutes. Overall, oral health professionals play an essential role in promoting healthy practices among users through increasing patients’ awareness of khat’s adverse oral and systemic effects, and by providing education on the positive outcomes of cessation. The latter can be encouraged by offering support and referrals (Table 2).37,38 

TABLE 2. Khat Cessation Recommendations


A thorough understanding of cultural diversity is essential for safe and effective dental care. With this goal, awareness of the oral and systemic health effects of khat use will allow clinicians to accurately diagnose and treat this patient population.

When clinicians apply cultural competency training to oral healthcare, they help ensure effective management of culturally diverse patients, and can make personalized and appropriate recommendations.39 Specifically in regard to khat users, longitudinal and cohort-based studies are needed to further validate effective interventions. 


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From Decisions in Dentistry. September 2021;7(9)36-39.

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