fbpx
A peer-reviewed journal that offers evidence-based clinical information and continuing education for dentists.

Can Cancer Cells Be Turned Off?

A study led by scientists at the Case Comprehensive Cancer Center at Case Western Reserve University in Cleveland, Ohio, and the University of Michigan Rogel Cancer Center in Ann Arbor have identified a binding site where drug compounds could stabilize a key braking mechanism in cancer cells.

0

A study led by scientists at the Case Comprehensive Cancer Center at Case Western Reserve University in Cleveland, Ohio, and the University of Michigan Rogel Cancer Center in Ann Arbor have identified a binding site where drug compounds could stabilize a key braking mechanism in cancer cells — essentially stopping the growth of many types of cancer.

Past studies showed certain molecules were capable of increasing the activity of the tumor suppressor protein PP2A, but researchers lacked information about the physical site where the molecules interact with the protein. As noted in “Selective PP2A Enhancement Through Biased Heterotrimer Stabilization,” this new discovery may lead to the development of anti-cancer drugs that enhance tumor suppressing proteins. In their research, the team used cryo-electron microscopy to render three-dimensional images of the tool-molecule DT-061 (which is bound to PP2A). This allowed them to see how parts of the protein come together and are stabilized. Reporting in Cell, they explain the binding pocket is where PP2A interacts with its phosphatase target to stabilize interactions between individual PP2A subunits.

In addition to cancer cells, PP2A also dysregulated cardiovascular and neurodegenerative diseases — a development that could lead to new medicines against these and other chronic conditions.

From Decisions in Dentistry. June 2020;6(6):7

Leave A Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy

SAVE BIG ON CE BEFORE 2025!

:
:
:
Coupon has expired

Promotional Period: 12/14/24 – 12/31/24

Get Special CE Savings!