PRF Is a Game-Changer in Endodontic Healing
Platelet-rich fibrin (PRF) is revolutionizing root canal and surgical endodontic treatments by enhancing healing, supporting tissue regeneration, and improving clinical outcomes. From regenerative pulp therapy to accelerated recovery after apicoectomy, PRF offers a powerful biological boost to traditional techniques.
Platelet-rich fibrin (PRF) has been effectively used in conjunction with other materials for root canal treatments, leading to improved clinical outcomes. For example, PRF combined with calcium hydroxide has shown enhanced results in promoting periapical healing. Additionally, PRF can be used as a scaffold for regenerative endodontic procedures, supporting the regeneration of pulp-dentin complex in immature teeth with necrotic pulps.1
Traditional methods, like apexification, have aimed to stimulate the formation of a calcific barrier at the root apex. However, newer techniques involving biological materials such as PRF and demineralized bone matrix (DMBM) are emerging as promising alternatives. In a case report on an 18-year-old man who presented with a fractured upper central incisor with an open apex from previous trauma, apexification was performed using DMBM and PRF along with mineral trioxide aggregate (MTA) as an apical barrier. After removal of necrotic pulp tissue, irrigating with sodium hypochlorite, and placing a calcium hydroxide medicament, a mixture of DMBM and PRF was placed into the canal to form an apical barrier, followed by MTA placement and final restoration. During the subsequent follow up visits, radiographic evidence indicated bone healing and complete apical closure after 3 months.2
In surgical endodontic procedures, such as apicoectomy, the application of PRF has enhanced healing of the surgical site. PRF serves as a matrix that supports new tissue growth and helps seal the surgical site, which reduces the risk of post-surgical complications and improves overall healing outcomes. In a recent case report, PRF was used in conjunction with an apicoectomy for treatment of a radicular cyst, resulting in an accelerated healing rate.3
References
- Kaur G, Thomas AR, Samson RS, et al. Efficacy of electronic apex locators in comparison with intraoral radiographs in working length determination- a systematic review and meta-analysis. BMC Oral Health. 2024;24:532.
- Sinha Y, Tilokani A, Pradhan PK, Majee N, Wandile B. Advanced management of open apex utilizing platelet-rich fibrin and bone graft as apical barriers with mineral trioxide aggregate (mta) obturation: a detailed case report. Cureus. 2024;16:e60883.
- Tewari S, Dhiman M, Bhagavatheeswaran S, Thakur V, Tewari S. Management of isolated labial mucosal fenestration by endodontic microsurgery along with platelet-rich fibrin and connective tissue graft: a series of four cases. Clin Adv Periodontics. 2022;12:194-203.
This originally appeared in Luan KW, Narvekar A. Unlocking the regenerative power of platelet-rich fibrin. Decisions in Dentistry. 2025;11(2):40-45.
