Dental Pulp Stem Cell Mitochondria Restore Neuronal Function in Parkinson’s Model
A new study reveals that mitochondria from human dental pulp stem cells can restore cellular energy, reduce oxidative stress, and promote neuron recovery in a Parkinson disease model. The findings suggest a novel, regenerative avenue for treating neurodegenerative disorders using dental-derived stem cells.
Researchers have uncovered a groundbreaking potential use for human dental pulp stem cells (hDPSCs) in combating Parkinson disease (PD). In a cellular model of PD, mitochondria isolated from hDPSCs were able to restore energy production, normalize oxidative stress, and enhance neuronal repair. The treated cells displayed improved mitochondrial activity, increased ATP output, and lower reactive oxygen species levels. Additionally, they showed longer neurite growth and greater expression of key neuroregenerative markers, including GAP43, tyrosine hydroxylase, synaptophysin, and dopamine transporter. Calcium imaging confirmed restored signaling function within neurons. These results indicate that mitochondria derived from hDPSCs not only survive and integrate within damaged neurons but also support synaptic recovery. This emerging approach may open the door to regenerative, cell-based treatments for neurodegenerative diseases, highlighting the remarkable therapeutic promise hidden within dental tissues. The study was published in Stem Cell Research & Therapy. Click here to read more.
