Modified Antibiotic Fights Antibiotic-Resistant Microbes

IMAGE BY SELVANEGRA/ISTOCK/GETTY IMAGES PLUS

Investigators at The Scripps Research Institute (TSRI) in La Jolla, California, may be closer to eliminating the threat of antibiotic-resistant microbes, as they recently discovered a way to structurally modify vancomycin to increase its effectiveness. Led by Dale Boger, PhD, cochair of TSRI’s Department of Chemistry, the team’s discovery pumps more power into an antibiotic that has been prescribed for 60 years — but one for which pathogens are now developing resistance.

This new modification “increases the durability of this antibiotic,” says Boger, whose previous studies showed adding two modifications to the drug makes it even more powerful. Published in Proceedings of the National Academy of Sciences, the study “Peripheral Modifications of [Ψ[CH2NH]Tpg4]Vancomycin With Added Synergistic Mechanisms of Action Provide Durable and Potent Antibiotics,” found that adding a third modification to vancomycin interferes with a bacterium’s cell wall in a novel way. This newly modified version killed both vancomycin-resistant enterococci bacteria, as well as the original forms of enterococci. “Organisms can’t simultaneously work to find a way around three independent mechanisms of action,” he says. “Even if they found a solution to one of these mechanisms, the organisms would still be killed by the other two.”

This discovery means clinicians would need to prescribe less of the antibiotic to fend off infection, according to researchers.

From Decisions in Dentistry. July 2017;3(7):9.

Add a Comment

Your email address will not be published. Required fields are marked *

University at Buffalo Receives Grant to Study ‘Dark Matter of Biology’

BUFFALO, N.Y. – A University at Buffalo (UB)-led team has received...

Robert M. Taft Installed as President of the American College of Prosthodontists

Navy Veteran to Lead the American College of Prosthodontists for the...

Georgia School of Orthodontics Unveils State-of-the-Art Gwinnett Clinic with Grand Opening

ATLANTA, Nov. 21, 2017 /PRNewswire/ — The Georgia School of Orthodontics (GSO) will...

Got a Toothache? There’s a Saint for That

New Online Exhibit in the Dugoni School’s “Virtual Dental Museum” Spotlights...

LANAP and LAPIP Protocols: Laser Gum Disease Protocols

Over 50% of US adults have gum disease.  Offer your patients...

IRIS HD USB 3.0 Intraoral Camera

Experience the Clarity in High Definition The new IRIS HD USB...

A New Adhesive/Primer Ideal for Indirect Restorations

At BISCO, adhesion is our passion. BISCO prides itself on developing...

KDZ Bruxer® Aesthetic

Bring the strength of full-contour zirconia into the facial zone with...