Porphyromonas gingivalis May Drive Alzheimer’s Disease

LOUISVILLE, Ky. — A paper published in Science Advances details how researchers identified Porphyromonas gingivalis (P. gingivalis) — a bacterium commonly associated with periodontitis — in the brains of patients with Alzheimer’s disease.

In animal models, oral P. gingivalis infection led to brain colonization and increased production of amyloid beta (Aβ), a component of the amyloid plaques commonly associated with Alzheimer’s. The team also found the organism’s toxic enzymes in the neurons of patients with the disease. These neurons, gingipains, are secreted and transported to outer bacterial membrane surfaces and have been shown to mediate the toxicity of P. gingivalis in a variety of cells, according to researchers. 

University of Louisville researcher Jan Potempa, PhD, who works in the Department of Oral Immunology and Infectious Diseases in the School of Dentistry, was part of the team of international scientists led by Cortexyme Inc, a privately held, clinical-stage pharmaceutical company. “We now have strong evidence connecting P. gingivalis and Alzheimer’s pathogenesis, but more research needs to be done before P. gingivalis is explicitly implicated in the causation or morbidity of Alzheimer’s disease,” says Potempa.  

Read the paper at http://advances.sciencemag.org/content/5/1/eaau3333

Add a Comment

Your email address will not be published. Required fields are marked *

ADA Foundation Awards $120,000 in Funding to Eight Organizations 

 The ADA Foundation has awarded a total of $120,000 in funding...

A child smiling
CDC Cautions That Kids Are Using Too Much Toothpaste

Almost 40% or children between the ages of 3 and 6...

Jordan Baugh Joins American Dental Association

The American Dental Association (ADA) has named Jordan Baugh as its...

Study Examines Oral Health and Frailty

Researchers with the Department of Dentistry and Oral Surgery at Hyogo...

DentiMax
DentiMax Inc Complete Cloud Software Empowers Dentists

DentiMax Inc offers a complete, all-in-one, practice management and imaging cloud...

VIZ Intraoral Scanner
VIZ Intraoral Scanner from Adin Digital

The VIZ Intraoral Scanner from Adin Digital combines innovative imaging technologies,...

Sunset Dental Lab
Combination Partial from Sunset Dental Lab

Many patients who need a partial denture complain about the unsightly...

Etch e1
Etch e1 from eDentalProducts.com

The product, e1, manufactured by eDentalProducts.com is a 37% phosphoric acid etching...