University at Buffalo Receives Grant to Study ‘Dark Matter of Biology’

RANDYPHOTOS/GETTY IMAGES

BUFFALO, N.Y. – A University at Buffalo (UB)-led team has received a $1.35 million grant from the National Institutes of Health Common Fund for Glycoscience to increase scientific understanding of glycans, a class of biomolecules that help bacteria attach to host surfaces, including those in the oral cavity. The project includes additional investigators from the University of California, San Francisco, University of California, San Diego, University of California, Davis, University of Maryland, Emory University and Cornell University.

Under the 3-year grant, researchers will collect oral bacteria from humans, horses, cows, sheep, rodents and other mammals, with the underlying goal to harness tools that help researchers examine how these microorganisms bind to glycans to form dental biofilms that increase the risk of caries and periodontal disease.

According to UB News, the study will use “friendly bacteria” harvested from the oral cavities of humans and animals to mine for serine-rich repeat (SRR) proteins. Using genetic information, researchers will artificially reproduce the variable, glycan-binding pockets of SRR proteins. After testing the proteins for their ability to bind to their target glycans, the adhesins will be mass-produced to create affordable, easy-to-use toolkits for scientists who are interested in glycan analysis, but lack expertise in glycoscience.

Add a Comment

Your email address will not be published. Required fields are marked *

Sonendo and TDO Software Expand Their Strategic Partnership

LAGUNA HILLS, Calif., Oct. 18, 2018 — Sonendo®, developer of the...

CDHP Brief Urges Prioritizing Pregnant Women’s Oral Health

Maintaining oral health during pregnancy is critical, as untreated dental disease...

OHA Advocates for Oral Health Equity on Capitol Hill

CHICAGO, October 17, 2018 — Earlier this month, Oral Heath America...

Chai Elected to National Academy of Medicine

Yang Chai, PhD, DDS, associate dean of research at Herman Ostrow...

LANAP and LAPIP Protocols: Laser Gum Disease Protocols

Over 50% of US adults have gum disease.  Offer your patients...

IRIS HD USB 3.0 Intraoral Camera

Experience the Clarity in High Definition The new IRIS HD USB...

A New Adhesive/Primer Ideal for Indirect Restorations

At BISCO, adhesion is our passion. BISCO prides itself on developing...

KDZ Bruxer® Aesthetic

Bring the strength of full-contour zirconia into the facial zone with...