Researchers Identify Possible New HIV Therapy

IMAGE BY CGTOOLBOX/ISTOCK/GETTY IMAGES PLUS

Investigators in the Division of Infectious Diseases at the University of North Carolina (UNC) School of Medicine have found that macrophages, in addition to T cells, act as a reservoir for the human immunodeficiency virus (HIV). These findings could potentially shift the focus from clearing the virus from T cells to also eradicating it from macrophage-large white blood cells found throughout the body, including the liver, bone marrow, lung, and brain.

Published in Nature Medicine, the study, “HIV Persistence in Tissue Macrophages of Humanized Myeloid-Only Mice During Antiretroviral Therapy,” focused on how macrophages would respond to antiretroviral therapy (ART). Led by J. Victor Garcia, PhD, professor of medicine, microbiology and immunology at UNC School of Medicine, researchers used a mouse model lacking T cells to show that ART suppressed HIV replication in tissue macrophages. Viral rebound occurred in one third of the subject animals when HIV treatment was interrupted, according to the study.

“This is the first report demonstrating that tissue macrophages can be infected, and that they respond to antiretroviral therapy,” notes Jenna Honeycutt, PhD, the study’s lead author and postdoctoral research associate in the UNC Division of Infectious Diseases. “In addition, it shows that productively infected macrophages can persist despite ART — and, most importantly, that they can reinitiate and sustain infection upon therapy interruption, even in the absence of T cells — the major target of HIV infection.”

Add a Comment

Your email address will not be published. Required fields are marked *

Colgate and Academy for Academic Leadership Launch Online Faculty Training Program to Help Develop the Foundations of Clinical Research

New York, New York—Colgate-Palmolive has announced the launch of an online faculty...

No Link Found Between Academic Test Results and Early Oral Cleft Surgery 

 The Cleft Palate–Craniofacial Journal – Researchers have often suspected that early exposure...

OSAP Announces Recipients of Infection Control Leadership Awards 

July 11, 2017: (ATLANTA, GA) — The Organization for Safety, Asepsis...

Researchers Identify Promising Target to Protect Bone in Patients With Diabetes 

Researchers at New York University College of Dentistry (NYU Dentistry) have...

LANAP and LAPIP Protocols: Laser Gum Disease Protocols

Over 50% of US adults have gum disease.  Offer your patients...

IRIS HD USB 3.0 Intraoral Camera

Experience the Clarity in High Definition The new IRIS HD USB...

A New Adhesive/Primer Ideal for Indirect Restorations

At BISCO, adhesion is our passion. BISCO prides itself on developing...

KDZ Bruxer® Aesthetic

Bring the strength of full-contour zirconia into the facial zone with...